Justus R. Hope discusses the potential of repurposed drugs, such as ivermectin and fenbendazole, in treating terminal cancers by targeting the metabolic drivers of cancer.

The Metabolic Theory of Cancer, described by Dr. Pierre Kory, states that cancer uses sugar and glutamine as fuel and that cancer cells have defective mitochondria and cannot metabolise ketone bodies.

Dr. Thomas Seyfried recommends starving cancer cells by restricting sugar and glutamine and feeding the body with ketones produced through fat consumption or fasting.

Supplements like green tea, curcumin and vitamins can be added to target cancer stem cells, and repurposed drugs like doxycycline and metformin have shown anti-cancer effects.

A low-seed-oil ketogenic diet is recommended, and therapeutic ketosis can act synergistically with conventional cancer treatments to enhance cancer management.

Fasting, exercise and vitamins like vitamin C and D have been identified as effective interventions in cancer treatment and prevention, with fasting being a potent stimulator of autophagy and P53 tumour suppressor function.

When Ivermectin and Fenbendazole Aren’t Enough

Justus R. Hope, who self-describes as a physician, writer and human rights advocate, publishes articles on a Substack page about repurposing life-saving generic drugs, among others. 

Over the past few weeks, he/she has been publishing articles reviewing summaries artificial intelligence has generated in response to queries about ivermectin and fenbendazole for treating cancer and, when those are not enough, other treatments for terminal cancer. 

The following are the articles in the series so far, beginning with an article about ivermectin and fenbendazole.  Unfortunately, the bulk of the articles are behind a paywall.  We have based our article on what is free to read in Justus R. Hope’s articles.

• AI Supports Ivermectin & Fenbendazole for Terminal Cancer
• When Ivermectin & Fenbendazole Aren’t Enough – Part 1
• When Ivermectin & Fenbendazole Aren’t Enough – Part 2
• When Ivermectin & Fenbendazole Aren’t Enough – Part 3

Fenbendazole is a broad-spectrum benzimidazole anthelmintic used to treat various gastrointestinal parasites in animals such as dogs, cats, horses, cattle and other species. It has gained interest in human medicine for its potential anticancer effects. Studies have shown that it can inhibit glycolysis, down-regulate glucose uptake, induce oxidative stress and enhance apoptosis in cancer cells. However, fenbendazole is not currently approved for use in humans by major ‍regulatory bodies such as the US Food and Drug Administration (“FDA”) or the European Medicines Agency (“EMA”).

Read more: Fenbendazole, ScienceDirect

Ivermectin is an antiparasitic drug discovered in the 1970s and approved for human use in 1987. It is used to treat a variety of parasitic infections, including river blindness (onchocerciasis), strongyloidiasis, scabies and head lice.  However, it is far more than an antiparasitic drug; this multifaceted “wonder drug” continues to surprise and exceed expectations. Since the first decade of the 21^st century, the scientific community have begun to recognise the unmatched value of this extraordinary drug. Today, it is recognised that few, if any, other drugs can rival ivermectin for its beneficial impact on human health and welfare.

Read more: Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations, The Journal of Antibiotics, 15 February 2017

“When discussing cancer with patients, many seem to be missing the greatest advance in cancer care in our lifetime – the advent of repurposed drug treatments,” Justus R. Hope said.  “No one questions the standard oncology care of surgery, chemotherapy, and radiation, despite their toxic side effects and often dismal success. Patients remain unaware that cancer is driven by metabolism, and the most successful repurposed drug treatments target this.”

He went on to explain that repurposed drugs, such as ivermectin and fenbendazole, have been successfully used to treat terminal cancers worldwide, targeting the metabolic drivers of cancer.  These treatments have shown promise in resolving terminal cancers of various types, including colon, brain, pancreas, breast and prostate cancer.

Mainstream medicine often misunderstands the biology of cancer, believing it to be a genetic mutation rather than a metabolic disorder caused by defective mitochondria.  As a result, many oncologists are unable to provide patients with accurate information about the best diet and lifestyle strategies to prevent or treat cancer and instead often recommend standard treatments like chemotherapy, radiation, and surgery.

And despite the rising popularity of repurposed drugs like ivermectin and fenbendazole, these treatments are not the most important keys to addressing cancer; a deeper understanding of the disease’s metabolic nature is necessary, Justus R. Hope said.

The Metabolic Theory of Cancer, described by Dr. Pierre Kory, states that cancer uses only two types of fuel to grow: sugar and glutamine, and that cancer cells have defective mitochondria and cannot metabolise ketone bodies. Dr. Thomas Seyfried recommends starving cancer cells by restricting sugar and glutamine while feeding the body with ketones produced through fat consumption or fasting.

Dr. Seyfried also dispels the notion that cancer is a parasitic disease and responds to antiparasitic drugs. He clarifies that both cancer and parasitic worms depend on fermentation metabolism, and so drugs that block this tend to kill both.  Justus R. Hope added that drugs like ivermectin and mebendazole, which is chemically related to fenbendazole. can interfere with cancer metabolism.

Dr. Seyfried stresses the importance of cutting off cancer’s fuel supply through diet and lifestyle changes.

To effectively combat cancer, it is crucial to eliminate sugar and glutamine from one’s diet, as these are the primary sources of fuel for cancer cells.  Avoiding sugar requires careful attention to hidden sources, such as those found in sauces, soups, crackers, and high fructose corn syrup, which also contains glyphosate-loaded poisons.  Avoiding glutamine is more challenging, as it is the most abundant amino acid and a breakdown product of protein, but can be achieved through a ketogenic diet and intermittent or overnight fasting.  Water fasts are the most effective method for starving cancer, but a ketogenic diet with intermittent or overnight fasting is a viable alternative.

Justus R. Hope provided an unofficial case study of Kevin Hennings who beat his stage 4 colon cancer using a fenbendazole cocktail. Hennings adopted a 20-hour daily overnight fasting regimen and a ketogenic diet.  Hennings has revised his successful cancer protocol building upon the fenbendazole cocktail approach popularised by Joe Tippens but incorporates the necessary diet and lifestyle changes recommended by Dr. Seyfried’s studies.  The revised repurposed drug protocol Hennings adopted includes specific dosages for Berberine, ivermectin and dimethyl sulphoxide (“DMSO”).

Read more: DMSO on The Exposé

In the second article about “when ivermectin and fenbendazole aren’t enough,”  Justus R. Hope explained that cancer stem cells (“CSCs”) are a primary cause of cancer recurrence and spread, and conventional treatments like chemotherapy, radiation, and surgery are ineffective in targeting them.

Surgery can stimulate CSCs, while radiation and chemotherapy also have a similar effect, making CSCs the “roots of cancer” that can regrow the tumour.

Repurposed drugs like Ivermectin target CSCs through different pathways, making it effective in late-stage cancers, whereas fenbendazole has a lesser effect on CSCs but more than makes up for this by interfering with cancer’s metabolism and stimulating P53 activity.

To increase the chances of success, it is recommended to target more CSC pathways, and supplements like green tea, curcumin and various vitamins can be added to achieve this.

Dr. Paul Marik’s book, ‘Cancer Care’, lists several repurposed drugs that can attack CSCs, including green tea extract, melatonin, vitamin D3, metformin, curcumin and others.

In his book, ‘Surviving Cancer, COVID-19, and Disease: The Repurposed Drug Revolution’, Justus R. Hope highlights the anti-cancer clinical effect of metformin and, notably, its effect against CSCs.

Doxycycline also has strong anti-CSC activity, particularly when combined with tiny doses of azithromycin and vitamin C.

Studies have shown that combining doxycycline with vitamin C can result in a 90% reduction of CSC, making it a potential “game changer” in cancer treatment.  The combination of doxycycline and vitamin C is effective in reducing CSCs without harming beneficial gut bacteria or causing drug resistance as only small doses, such as 40 mg per day, are necessary.

Read more: Dr. Paul Marik’s book ‘Cancer Care’ is now available as a FREE download

In the third article about “when ivermectin and fenbendazole aren’t enough,”  Justus R. Hope discusses the conventional approach to cancer treatment, which includes chemotherapy, radiation, and surgery, being challenged by medical professionals like Dr. Marik and Dr. William Makis, who have demonstrated the effectiveness of alternative treatments.

Using an artificial intelligence (“AI”) ranking of these alternative treatments, Justus R. Hope gives his opinion on them and whether he believes AI has ranked them correctly.  He begins his review with the bottom of the list, number 13, and works his way to number 1.

Bottom-Ranked Interventions: HBOT and Ketogenic Diet

The bottom-ranked interventions, #11 through #13, include Hyperbaric Oxygen Therapy (“HBOT”), the ketogenic diet and other treatments.

HBOT, ranked #13, has mixed results in cancer treatment, with some evidence suggesting it can enhance radiation therapy, but also potentially increasing toxicity when combined with certain chemotherapies.

The ketogenic diet, ranked #12, has primarily metabolic benefits, but its effectiveness against cancer may be influenced by the type of fat consumed, with diets high in linoleic acid (“LA”) potentially increasing cancer risk.  AI confirms that diets high in LA, found in seed oils such as canola, corn, and sunflower oil, are associated with increased risks for prostate cancer, dysbiosis and colorectal cancer.  To maximise the effectiveness of a ketogenic diet against cancer, it is essential to keep LA and overall polyunsaturated fatty acid (“PUFA”) intake as low as possible.

People with a history of cancer must actively target cancer stem cells daily to avoid recurrence, and everyone should strive to maximise their P53 natural tumour suppressor function to prevent cancer.

A low-seed-oil ketogenic diet is recommended over a general ketogenic diet, as it is preferred and has shown benefits in studies, with Dr. Marik highly recommending it for its association with long-term survival in patients with metastatic non-small cell lung cancer and glioblastoma.

Therapeutic ketosis can act synergistically with conventional chemotherapeutic drugs, irradiation and surgery to enhance cancer management, improving both progression-free and overall survival.

Intravenous Vitamin C and Other Vitamins

Intravenous (“IV”) vitamin C is a controversial topic, but a PubMed study linked it to enhanced cisplatinum anti-cancer activity via P53 upregulation, and Dr. Linus Pauling’s study showed substantial increases in cancer survival with IV vitamin C.

IV vitamin C can produce oxidising blood levels 50 times higher than oral dosing, making it more effective in cancer treatment, whereas oral vitamin C typically functions as an antioxidant and does not produce sufficient blood levels to kill cancer stem cells.

A combination of low-dose doxycycline and oral vitamin C may be effective in eradicating 90% of cancer stem cells, as doxycycline sensitises oral vitamin C to function as a pro-oxidant.

Dr. Marik advises against using vitamin E, ranked by AI as #10, during chemotherapy, as it can undermine the oxidant effectiveness of treatment, while vitamin D is considered a powerful weapon in cancer prevention and treatment, with a recent study showing a strong cancer stem cell inhibiting effect.

Vitamin D is ranked #1 in Cancer Care, contradicting AI’s lower ranking of #9, and is considered crucial in cancer prevention and treatment. 

Dr. Marik highlights the broad anti-neoplastic activity of vitamin D, including its ability to induce apoptosis, inhibit CSCs, and decrease proliferation, angiogenesis and metastatic potential.  Vitamin D’s anti-neoplastic activity is achieved through binding to the vitamin D receptor, leading to transcriptional activation and repression of target genes.

Zinc, Melatonin and Doxycycline

Zinc is ranked #7 by AI for its anti-CSC activity, and it also interacts with P53, although less so than melatonin and green tea, which are ranked #6 and #5, respectively.

Melatonin is essential for maintaining healthy mitochondria, and its daily supplementation, even in microdoses, is recommended to prevent cancer.

Doxycycline, ranked #4 by AI, is a repurposed drug that can eradicate CSCs when used with oral vitamin C and has been employed in the Care Oncology Clinic’s 4-Drug Protocol.

Fasting, Exercise, and Cancer Risk

The top three anti-CSC and pro-P53 supplements or interventions are fasting (#1), exercise (#2), and curcumin (#3), with fasting being a potent stimulator of autophagy and P53 tumour suppressor function.

Dr. Marik emphasises the benefits of fasting, including promoting immune system homeostasis, improving mitochondrial health and increasing stem cell production.  Regular water fasts, such as 3 days per month, are recommended by Dr. Makis for those with advanced cancer.

Moderate-intensity exercises, such as walking, swimming or cycling, are recommended by AI, as they trigger protective functions of P53 and promote mitochondrial function and aerobic metabolism.

Paradoxically, high-intensity exercises, such as marathon running, may actually promote cancer risk, according to AI’s findings.

Anecdotal reports have confirmed cases of Stage 4 cancer development in young long-distance runners, including James Templeton and Diego Mesa, who were both marathon runners and considered themselves healthy before being diagnosed with terminal cancer.

These cases, along with three other famous young elite athletes identified by AI  – Sir Chris Hoy, Govind Sandhu, Liam Hendriks and Mark Carles –  suggest a potential link between intense aerobic exercise and an increased risk of cancer.

AI has identified multiple reasons why intense aerobic exercise may promote cancer, although these reasons are not included in the free-to-read section of Justus R. Hope’s article.

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Rhoda Wilson

While previously it was a hobby culminating in writing articles for Wikipedia (until things made a drastic and undeniable turn in 2020) and a few books for private consumption, since March 2020 I have become a full-time researcher and writer in reaction to the global takeover that came into full view with the introduction of covid-19. For most of my life, I have tried to raise awareness that a small group of people planned to take over the world for their own benefit. There was no way I was going to sit back quietly and simply let them do it once they made their final move.

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