Despite decades of statin use costing approximately $25 billion annually in America alone, heart disease remains the leading cause of death, suggesting the cholesterol hypothesis that drives statin prescriptions is fundamentally flawed.

Studies show that lowering cholesterol with statins does not reduce heart disease, and yet these findings are ignored while statin guidelines are created by experts paid by pharmaceutical manufacturers.

Malcolm Kendrick’s clotting model provides a superior explanation for heart disease: atherosclerotic plaques result from repeated damage to blood vessel linings, which the body repairs with layers of clots.

The medical establishment dismisses widespread reports of statin injuries as “nocebo effects,” paralleling how covid-19 vaccine injuries were dismissed as “anxiety,” despite extensive evidence corroborating the injuries.

The actual causes of heart disease – fine particulate matter from pollution and cigarettes, lead exposure, chronic stress and endothelial damage – receive minimal research funding because effective interventions cannot be patented and sold as expensive pharmaceuticals like statins.

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Statins, Cholesterol and the Real Cause of Heart Disease

By A Midwestern Doctor, as published by Mercola.com on 13 February 2026

Table of Contents

Frequently in science, fundamental facts are altered to create a profitable industry. Recently, I showed how this occurs with blood pressure: rather than causing arterial damage, high blood pressure is a response to arterial damage that ensures damaged arteries can still deliver blood to the tissues.

In turn, rather than helping patients, aggressively lowering blood pressure can be quite harmful. In this article, I will look at the other half of the coin, statins, cholesterol, and heart disease – something that harms so many Americans; it was poignantly discussed by Comedian Jimmy Dore.

Cholesterol and Heart Disease

Frequently, when an industry harms many people, it will create a scapegoat to deflect blame. Once this happens, a variety of other sectors will jump on the bandwagon and create an unshakable societal dogma.

For example, the health of a population (or if they are being poisoned by environmental toxins) determines how easily an infectious disease can sweep through a population and who is susceptible to it, but reframing infectious diseases as a “deficiency of vaccines” it both takes the (costly) onus off the industries to clean up the society and simultaneously allows them to get rich promoting the pharmaceutical products that “manage” each epidemic and the even larger epidemic of chronic diseases caused by those vaccines (discussed in detail HERE).

Note: The major decline in infectious illness credited to vaccines was actually the result of improved public sanitation; when the data are examined (e.g., for smallpox) those early vaccination campaigns made outcomes worse, not better.

In the 1960s and 1970s, a debate emerged over the causes of heart disease. On one side, John Yudkin effectively argued that the sugar being added to our food by the processed food industry was the chief culprit.¹ On the other side, Ancel Keys (who attacked Yudkin’s work) argued that it was due to saturated fat and cholesterol.²

Note: Leaders in the field of natural medicine have made a strong case that this spike came from the mass adoption of seed oils³ (which, thanks to our unprecedented political climate, is at last being discussed on the mainstream news⁴). Likewise, some attribute this increase to the advent of water chlorination.⁵

Ancel Keys won. Yudkin’s work was largely dismissed and Keys became nutritional dogma. A large part of Key’s victory was based on his study of seven countries (Italy, Greece, the former Yugoslavia, the Netherlands, Finland, America and Japan), which showed that as saturated fat consumption increased, heart disease increased in a linear fashion.

However, this result was simply a product of the countries Keys chose (e.g., if Finland, Israel, the Netherlands, Germany, Switzerland, France and Sweden had been chosen, the opposite correlation would have been found).

Fortunately, it’s gradually become recognised that Keys did not accurately report his data. For example, recently, an unpublished 56-month randomised study of 9,423 adults living in state mental hospitals or a nursing home (which made it possible to rigidly control their diets) that Keys directed was unearthed.⁶

It found that replacing half of one’s animal (saturated) fats with seed oil (e.g., corn oil) lowered their cholesterol, but for every 30 points it dropped, their risk of death increased by 22% (which roughly translates to each 1% drop in cholesterol raising the risk of death by 1%).

Note: Another (unpublished) study from the 1970s (of 458 Australians) found that partially replacing dietary saturated fat with seed oils increased the risk of dying by 17.6%.⁷

Likewise, recently, one of the most prestigious medical journals in the world published internal sugar industry documents.⁸ They showed the sugar industry had used bribes to make scientists place the blame for heart disease on fat so Yudkin’s work would not threaten the sugar industry.⁹ Remarkably, it is now generally accepted that Yudkin was right but nonetheless, our medical guidelines are still largely based on Keys’ work.

Likewise, the need to lower cholesterol to prevent heart disease is still a dogma within cardiology,^{10,11,12,13,14,15} despite things like this Lancet study¹⁶ which in 1986 showed: “During 10 years of follow-up from Dec 1, 1986 to Oct 1, 1996, a total of 642 participants died. Each 1 mmol/L increase in total cholesterol corresponded to a 15% decrease in mortality (risk ratio 0-85 [95% Cl 0·79-0·91]).”

Statins Marketing

Once a drug is identified that can “beneficially” change a number, medical practice guidelines will inevitably shift to prioritising treating that number in more and more people. For example, this is what happened with blood pressure:

Prior to statins, it was difficult to reliably lower cholesterol but once they were introduced, research rapidly emerged arguing for a greater and greater need to lower cholesterol (and put more people on statins).

Note: In 2008 to 2009, 12% of Americans over 40 reported taking a statin, whereas in 2018 to 2019, that figure increased to 35%,¹⁷ and Americans now spend approximately 25 billion annually on statins.¹⁸

In tandem, a cancel culture (reminiscent of what we saw with the covid vaccines) has been created where anyone who challenges the use of Statins is immediately labelled as a “statin denier,” accused of being a mass murderer and effectively cancelled. Here, dissident cardiologist Aseem Malhotra discusses the dirty parallels between these two industries with Joe Rogan:

As such, beyond doctors being forced to follow these guidelines, patients often are too. Ideological doctors will retaliate against patients who do not take statins (similar to how unvaccinated patients were reprehensibly denied essential medical care during covid-19), employers sometimes require cholesterol numbers to meet a certain threshold for employment, and life insurance policies often penalise those with “unsafe” cholesterol numbers.

Statin Injuries

This status quo is inexcusable as statins have a very high rate of injury. For example, the existing studies find between a 5% to 30% rate of injuries,¹⁹ and Dr. Malhotra, having gone through all the existing evidence, estimates that 20% of statin users are injured by them.

Likewise, statins are well known for having a high percentage of patients discontinue the drugs due to their side effects (e.g., one large study found 44.7% of older adults discontinue the drugs within a year of starting them,²⁰ while another large study of adults of all ages found 47% discontinued within a year).²¹

Statins, in turn, are linked to a large number of complications that have been well-characterised (e.g., mechanistically) and described throughout the medical literature.^{22,23,24,25,26,27,28} One group of side effects are those perceived by the patient (which often make them want to stop using the medications). These include:

• A high incidence of muscle pain^{29,30,31,32,33,34,35}
• Fatigue^36,37 especially with exertion and exercise³⁸
• Muscle inflammation (whose cause remains “unknown”)^39,40
• Autoimmune muscle damage^41,42,43,44
• Psychiatric and neurologic issues such as depression, confusion, aggression, and memory loss^{45,46,47,48,49,50,51,52,53}
• Severe irritability⁵⁴
• Sleep issues⁵⁵
• Musculoskeletal disorders and injuries^56,57
• Sudden (sensorineural) hearing loss⁵⁸
• Gastrointestinal distress⁵⁹

The other group are those not overtly noticed by the patient. These include:

• Type 2 diabetes^{60,61,62,63,64} particularly in women^65,66,67
• Cancer^68,69,70,71
• Liver dysfunction and failure^72,73
• Cataracts^74,75
• ALS-like conditions and other central motor disorders (e.g., Parkinson’s disease and cerebellar ataxia)^{76,77,78,79,80}
• Lupus-like syndrome⁸¹
• Susceptibility to herpes zoster (shingles)^82,83,84
• Interstitial cystitis⁸⁵
• Polymyalgia rheumatica⁸⁶
• Kidney injury^87,88
• Renal failure⁸⁹

From the start, I noticed statin patients often reported numbness, muscle pain or cognitive issues after starting these drugs, which resolved once they stopped. When this was brought up with their doctors, the response was often hostile, with doctors insisting statins couldn’t be the cause (citing their own experience of never having seen this happen to a patient) or claiming the patient needed to continue the medication regardless to avoid a heart attack.

In turn, as the years went by, I saw increasingly elaborate excuses being created to protect the statins from an ever-increasing awareness of their dangers. A common one was the “nocebo effect” – the idea that negative expectations caused the reported symptoms. For example, I lost count of how many doctors I knew who cited this 2016 study⁹⁰ when patients stated they had been injured.

The nocebo effect is the opposite of the placebo effect. While the placebo effect occurs when a person experiences positive outcomes from a treatment because they believe it will help, the nocebo effect happens when negative outcomes arise simply because a person expects harm from a treatment, even if the treatment itself is harmless or ineffective.

This theory was used to dismiss patients’ experiences despite the fact that many were unaware of possible side effects until they occurred and then looked them up.

If you take this story and replace “statin” with covid-19 vaccines, you will see it is essentially what everyone has experienced over the last four years (e.g., I lost count of how many times vaccine myocarditis was diagnosed as “anxiety”).

Note: Two adverse event reporting systems exist for adverse reactions to pharmaceuticals, MedWatch⁹¹ and FAERS.⁹² Like VAERS, they suffer from severe underreporting (it is estimated only 1% to 10% of adverse events are reported to them), but nonetheless, thousands of (ignored) reports can be found there of the common injuries which result from statins.⁹³

“Cholesterol” Plaques

Many medical beliefs emerge from the pharmaceutical marketing departments. For example, the widespread belief that depression is due to a “chemical imbalance” is actually false and never had any evidence supporting it.

Likewise, they made us believe heart disease results from fat clogging the arteries, much like it does for a drain pipe, as this metaphor is easy for everyone to visualise and immediately elicits a sense of disgust.

However, given that there is no link between cholesterol and heart disease, is it necessarily true? Malcolm Kendrick, MD, in turn, discovered that the well-known risk factors for heart disease do not corroborate the standard model.⁹⁴ For example, to calculate the risk of heart disease, England combines the adjustable risks for heart disease (e.g., age) with the conditions commonly associated with causing heart disease.⁹⁵

Likewise, in a 2017 study, the records of 378,256 English patients were analysed by an AI system to identify which characteristics were associated with the highest risk of a cardiovascular event over the next 10 years. The ten greatest risk factors (in order) were:⁹⁶

From this, Kendrick concluded that the common thread was that many of these (e.g., lupus or cortisol) are associated with damage to blood vessels and impaired microcirculation (a consequence of such damage) rather than with cholesterol.⁹⁷

Presently, cardiology believes cholesterol somehow gets into a blood vessel and then damages it (leaving an atherosclerotic plaque). Kendrick saw that a forgotten model (that the medical profession largely buried) provides a much better explanation of the causes of heart disease:

1. Blood vessels get damaged.
2. The body repairs the damage with cholesterol-containing clots.
3. As clots heal, they are pulled inside the blood vessel wall, and a new layer of endothelium (blood vessel lining) grows over them.
4. As this occurs multiple times in the same area, the damage (plaques) under the blood vessel becomes more abnormal.

Some of the key points of evidence he uses to support this argument are:⁹⁸

• Most of the risk factors for heart disease overlap with things that would be expected to damage the blood vessel lining (endothelium).

• Plaques tend to form at arterial branch (junction) points, which are the parts of the artery that are subjected to the greatest shear stress.⁹⁹

• When you examine the components of a plaque, they are found to contain the same debris found in blood clots.^100,101,102

• There is no established mechanism for how cholesterol from the bloodstream can get under the endothelium. However, red blood cells (which play a key role in forming clots¹⁰³) contain a large amount of cholesterol (50% of the total amount in the bloodstream¹⁰⁴) and hence will bring it into clots that form.

• Plaques contain cholesterol crystals. These crystals can form only from free cholesterol,¹⁰⁵ which is present in red blood cells but not from the “bad” cholesterol that circulates in the bloodstream (contained within lipoproteins). Likewise, much of the cholesterol found in atherosclerotic plaques is free cholesterol.¹⁰⁶

• The remnants of lipoproteins that are found in plaques are not cholesterol lipoproteins but rather lipoprotein A, something the body uses to repair damage to the arterial walls.¹⁰⁷ This is supported by the fact that elevated blood lipoprotein A levels are associated with increased lipoprotein remnants in plaques¹⁰⁸ and that the specific marker of lipoprotein A is found to concentrate in atherosclerotic plaques.¹⁰⁹

Lipoprotein A, in turn, is problematic because while it can patch and repair arterial damage, it also makes clots resistant to subsequent degradation, guaranteeing that they will eventually be pulled under the endothelium and transformed into an atherosclerotic plaque (which may in turn explain why elevated lipoprotein A levels are associated with a three-fold increase in the risk of a heart attack or stroke¹¹⁰).

In short, a strong case can be made that our entire heart disease model rests on a variety of correlations that were erroneously assumed to demonstrate causation. Sadly, while the “correlation is not causation” mantra is frequently used to dismiss anything that challenges the orthodoxy, you will frequently find overtly false correlations that support the medical industry’s bottom line being treated as unquestionable dogmas.

Note: One of the best examples is the widespread belief that vaccines eliminated infectious disease, even though no correlation exists (whereas public sanitation directly correlates with the elimination of infectious diseases).

The Causes and Treatments of Heart Disease

Kendrick’s model essentially argues the following:

• Most cardiovascular disease results from the blood vessel lining becoming damaged (due to the atherosclerotic lesions) and losing the ability to perform the normal functions (e.g., nitric oxide secretion) that allow it to protect the circulation.

• Inflammation and periods of prolonged and severe stress (e.g., from mental illness, cigarettes or extreme social oppression) frequently damage the endothelium and hence contribute to heart disease.

• Heart attacks are due to blood clots (which frequently are a result of damaged endothelium) interrupting a critical blood supply to the heart.

Remarkably, most of Kendrick’s model is in complete agreement with the conventional cardiovascular disease paradigm; he just emphasises stress and inflammation rather than cholesterol, and prioritises treating the functional impairments of the blood vessels (e.g., reduced nitric oxide synthesis).

Note: Kendrick argues the small benefits experienced from statins are likely due to the drugs also having anti-inflammatory effects¹¹¹ and increasing endothelial nitric oxide.¹¹²

Similarly, smoking is well recognised to cause heart disease because it damages the blood vessels (e.g., by creating plaques and impairing their ability to make nitric oxide¹¹³) but we rarely ask why or note that similar damage has been repeatedly demonstrated with fine particulates from coal mines,¹¹⁴ breathing air in crowded cities,¹¹⁵ cooking with a wood burning stove¹¹⁶ or being exposed to wildfire smoke.¹¹⁷

Likewise, lead is quite damaging to the endothelium,^118,119 rapidly enters the bloodstream once inhaled¹²⁰ and a strong correlation exists between lead use in gasoline and heart disease in America.¹²¹

Note: It’s estimated that around 400,000 deaths each year in America are due to lead exposure.¹²² And in a study of 868 men, it was observed that high levels of lead exposure (assessed by its presence in the bones) increased their risk of dying by over 700%,¹²³ particularly since lead returns to the bloodstream as ageing bones break down.

Sadly, as you cannot sell drugs for any of these causes of heart disease, they rarely get mentioned and instead, almost all of the research and discussions on heart disease are directed at cholesterol.

Conclusion

Kendrick presciently argued that because of how much money has been invested in establishing the cholesterol hypothesis, the industry will never let it go. This, in short, accounts for why we continue to spend billions each on these drugs despite their benefit being almost non-existent (e.g., unbiased research shows taking statins for five years, on average, only extends life by 3 to 4 days¹²⁴ – and only in men)¹²⁵ and their harms being common and immense.

Fortunately, we have at last reached a point where real progress is being made. For example, despite immense institutional pushback, Make America Healthy Again (“MAHA”) recently updated the Federal Dietary Guidelines to at last correct the 50-year-mistake created by Keys’ doctored data and acknowledge the importance of consuming healthy animal fats.

The insatiable greed which birthed the unconscionable covid vaccines and their mandates has at last opened the public’s eyes to the marketing myths the pharmaceutical industry has bombarded us with from birth so we perpetually consume their products. Because of that, we at last have a once-in-a-lifetime opportunity to correct many of these disastrous policies, and as MAHA’s recent revision of the food pyramid shows (which I never imagined would occur), change is actually happening.

Unfortunately, decades of other disastrous health policies also need to be fixed and for that to happen, it is essential that we bring awareness to each of them. I sincerely thank each of you for allowing me to share the truth about statins with you; so many people I know have been hurt by them and with your help, we can at last end this.

Author’s Note: This is an abridged version of a longer article about the great cholesterol scam which goes into greater detail on the dangers of statins, the actual causes of heart disease, and the natural ways to safely heal the arterial system and prevent heart disease. That article and its additional references can be read HERE.

A Note from Dr. Mercola About the Author

A Midwestern Doctor (AMD) is a board-certified physician from the Midwest and a longtime reader of Mercola.com. I appreciate their exceptional insight on a wide range of topics and I’m grateful to share them. I also respect AMD’s desire to remain anonymous since AMD is still on the front lines treating patients. To find more of AMD’s work, be sure to check out The Forgotten Side of Medicine on Substack.

Sources and References:See HERE for all references

Featured image taken from ‘4 statin alternatives that lower cholesterol’, British Heart Foundation, 1 November 2024

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While previously it was a hobby culminating in writing articles for Wikipedia (until things made a drastic and undeniable turn in 2020) and a few books for private consumption, since March 2020 I have become a full-time researcher and writer in reaction to the global takeover that came into full view with the introduction of covid-19. For most of my life, I have tried to raise awareness that a small group of people planned to take over the world for their own benefit. There was no way I was going to sit back quietly and simply let them do it once they made their final move.

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