Nattokinase is a potent fibrinolytic enzyme extracted from natto, a traditional Japanese food made from fermented soyabeans using the bacterium Bacillus subtilis.
It is primarily used as a dietary supplement to support cardiovascular health by breaking down fibrin, the protein structure of blood clots, which may help improve blood circulation and reduce the risk of clot-related conditions.
More than three years ago, Dr. Peter McCullough identified nattokinase as an effective detoxification from covid injections.
Related: The First Published Detoxification Protocol to Help Clear Spike Protein from Cells and Tissues
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Dissolution of Spike Protein by Nattokinase
By Dr. Peter A. McCullough, 21 February 2023
Far and away the most common question I get from those who took one of the covid-19 vaccines is: “How do I get this out of my body”?
The mRNA and adenoviral DNA products were rolled out with no idea of how or when the body would ever break down the genetic code. The synthetic mRNA carried on lipid nanoparticles appears to be resistant to breakdown by human ribonucleases by design so the product would be long-lasting and produce the protein product of interest for a considerable time period.
This would be an advantage for a normal human protein being replaced in a rare genetic deficiency state (e.g. alpha galactosidase in Fabry’s disease). However, it is a big problem when the protein is the pathogenic SARS-CoV-2 spike protein. The adenoviral DNA (Janssen) should be broken down by deoxyribonuclease; however, this has not been exhaustively studied.
This leaves dissolution of spike protein as a therapeutic goal for the vaccine-injured. With the respiratory infection, Spike is processed and activated by cellular proteases including transmembrane serine protein 2 (TMPRSS2), cathepsin and furin. With vaccination, these systems may be avoided by systemic administration and production of spike protein within cells. As a result, the pathogenesis of vaccine injury syndromes is believed to be driven by accumulation of spike protein in cells, tissues and organs.
Nattokinase is an enzyme is produced by fermenting soyabeans with the bacterium Bacillus subtilis var. natto and has been available as an oral supplement. It degrades fibrinogen, factor VII, cytokines and factor VIII and has been studied for its cardiovascular benefits. Out of all the available therapies I have used in my practice and among all the proposed detoxification agents, I believe nattokinase and related peptides hold the greatest promise for patients at this time.
Tanikawa et al. examined the effect of nattokinase on the spike protein of SARS-CoV-2. In the first experiment, they demonstrated that the spike protein was degraded in a time- and dose-dependent manner in a cell lysate preparation that could be analogous to a vaccine recipient. The second experiment demonstrated that nattokinase degraded the spike protein in SARS-CoV-2-infected cells. This reproduced a similar study done by Oba and colleagues in 2021.
Nattokinase is dosed in fibrinolytic units (“FU”) per gramme and can vary according to purity. Kurosawa and colleagues have shown in humans that after a single oral dose of 2,000 FU, D-dimer concentrations at 6 and 8 hours, and blood fibrin/fibrinogen degradation products at 4 hours after administration elevated significantly (p < 0.05, respectively). Thus, an empiric starting dose could be 2,000 FU twice a day. Full pharmacokinetic and pharmacodynamic studies have not been completed, but several years of market use as an over-the-counter supplement suggests nattokinase is safe with the main caveat being excessive bleeding and cautions with concurrent anti-platelet and anti-coagulant drugs.
Based on these findings, nattokinase and similar products such as serrapeptase should undergo well-funded, accelerated preclinical and clinical development programs. The issue at hand is the urgency of time, similar to that with SARS-CoV-2 infection and empiric early therapy.
It will take up to 20 years to have a fully developed pharmaceutical profile to characterise the safety and efficacy of nattokinase in the treatment of vaccine injury and post-covid syndromes. A large number of people are sick now, and many believe empiric treatment is justified given sufficiently low risk of side effects and potentially high reward. My recommendation is to discuss this with your doctor or seek a specialist in holistic or naturopathic medicine who is experienced with the safety profile of nattokinase in a range of applications.
References:
- Tanikawa T, Kiba Y, Yu J, Hsu K, Chen S, Ishii A, Yokogawa T, Suzuki R, Inoue Y, Kitamura M. Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2. Molecules. 2022 Aug 24;27(17):5405. doi: 10.3390/molecules27175405. PMID: 36080170; PMCID: PMC9458005.
- Oba M, Rongduo W, Saito A, Okabayashi T, Yokota T, Yasuoka J, Sato Y, Nishifuji K, Wake H, Nibu Y, Mizutani T. Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro. Biochem Biophys Res Commun. 2021 Sep 17;570:21-25. doi: 10.1016/j.bbrc.2021.07.034. Epub 2021 Jul 13. PMID: 34271432; PMCID: PMC8276596.
- Kurosawa Y, Nirengi S, Homma T, Esaki K, Ohta M, Clark JF, Hamaoka T. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015 Jun 25;5:11601. doi: 10.1038/srep11601. PMID: 26109079; PMCID: PMC4479826.
About the Author
Peter McCullough, MD, MPH, is an internist, cardiologist, epidemiologist and media commentator. He is Chief Scientific Officer of The Wellness Company and President of The McCullough Foundation.
Featured image: Natto is the only significant dietary source of nattokinase. Source: Deposit Photos
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