Psilocybin is a naturally occurring compound found in over 200 species of fungi collectively known as “magic mushrooms.” It functions as a prodrug, meaning it is biologically inactive until ingested, at which point the body rapidly converts it into psilocin. Psilocin is the pharmacologically active compound responsible for the drug’s effects.
In 2000, psilocybin research in the US was resumed and in the following years, research has surged due to its potential as a treatment for various psychiatric disorders and addictions. In the following, Nicolas Hulscher highlights a case study of an 80-year-old woman who had been diagnosed with advanced Alzheimer’s.
“[She had] a remarkable and unexpected clinical response … following a single high-dose psilocybin intervention,” he writes.
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New Study: Advanced Alzheimer’s Patient Regained Speech, Memory, and Bladder Control After a Single Psilocybin Dose
By Nicolas Hulscher, 5 June 2026
A newly published case report in Frontiers in Neuroscience describes a remarkable and unexpected clinical response in an 80-year-old woman with advanced Alzheimer’s disease following a single high-dose psilocybin intervention.
The patient had lived with Alzheimer’s disease for approximately 10 years and experienced severe functional decline over the preceding five years. According to the report, she had become largely monosyllabic, demonstrated profound cognitive impairment, chronic urinary incontinence, impaired mobility, dysphagia, executive dysfunction and severe reduction in spontaneous communication and emotional engagement.
After receiving a single 5g oral dose of psilocybin-containing mushrooms (Enigma strain), the patient reportedly experienced rapid and sustained functional improvement across multiple domains.
During the acute phase, the patient entered a prolonged deep sleep-like state accompanied by profuse sweating and clinically suspected hyperthermia.
Then, approximately 19 hours later, something unexpected occurred.
The patient spontaneously awakened and began speaking for hours, engaging in autobiographical conversation and recalling memories that had not been expressed in years.
Over the following days, her family reported meaningful improvements in:
- Speech and communication.
- Memory and contextual recognition.
- Walking and mobility.
- Emotional connection and social engagement.
- Bladder control, after years of chronic urinary incontinence.
Most notably, the improvements were not merely immediate and fleeting.
At 1-month follow-up, bladder control reportedly remained restored and the patient was described as still functionally improved compared with baseline. Due to the persistence of meaningful benefits, a second supervised psilocybin session was performed one month later.
To be clear, this is one published case report, not a randomised controlled trial, and causality cannot be established.
Nevertheless, the implications are difficult to ignore.
There are currently no approved Alzheimer’s medications known to produce rapid, multi-domain improvements of this magnitude in advanced disease. Existing therapies may modestly slow decline or provide limited symptomatic benefit in some patients, but none are known to rapidly restore speech, continence, emotional engagement and functional capacity in a patient with advanced Alzheimer’s.
Two of my grandparents died with advanced Alzheimer’s disease, and every medication they were prescribed ultimately failed to meaningfully alter the course of decline. Millions of families across the world face the same devastating reality.
These findings urgently need replication. For millions watching a parent or loved one disappear to Alzheimer’s, even the possibility of restoring lost function warrants serious scientific investigation.
About the Author
Nicolas Hulscher, Master of Public Health (“MPH”), is an epidemiologist and Administrator at the McCullough Foundation, which publishes articles on a Substack page titled ‘Focal Points’.
Hulscher is known for his research on adverse events following covid vaccination, particularly focusing on myocarditis and other post-acute sequelae. He has been the lead author on several covid vaccination studies and a contributor to others. He has also co-authored research on the proximal origin of highly pathogenic avian influenza H5N1.
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Categories: Breaking News, Latest News, World News
Big pharma is the real disease of humanity, suppressing all the holistic remedies of the past in favour of petrochemical pharmacology which is never designed to cure but to maintain (a customer base).
Wonderful post RW!
Lithium Orotate ,5mg repeatedly ,over weeks does very similar .Alzheimers long term expert neurologist Michael Nehls came up with this .
Iherb .com does it very cheaply .
Nick H MUST comment on this treatment ,surely ,as MN has been very clear & findable on this ?
Meanwhile – even though living in NL – a pure source of the mushroom in capsule form ?
Dutch govt made non exact dosing of certain offshoots of mushroom in question available .
Dont trust any source to be pure ,unlaced .
Hi Kilquor, you say, “Wonderful post RW!” Thank you, but the credit must go to Nicholas Hulscher.
Dr. Paul Mason explains how diet can be used to prevent & reverse dementia including Alzheimer’s disease: https://www.youtube.com/watch?v=J_xu2zLlQAs
Avoiding chronic inflammation, oxidation stress, and glycation damage caused by carbohydrates, and seed oil consumption is key to preventing and reversing dementia.
Seed oils are often deceptively labeled as ‘vegetable” oils. Glycation damage occurs when sugar attaches to proteins in body tissues, permanently damaging them- until insulin levels drop low enough for long enough to allow the boy to break down the damaged tissue and rebuild it. This happens when people adopt a ketogenic diet and avoid eating for 16+ hours/day – or do water only fasts for several days.
Animal-source foods contain nutrients essential for optimal human development and function- including the brain. There is zero actual evidence that eating eggs or red meat causes any harm, but these, along with uncontaminated seafood (which may no longer exist), are the most nutritious foods. The brain is made mostly of fat and cholesterol – and heme iron found only in red meat, is needed by the body to make certain nero-transmitters.
Dr. Ede. MD – ‘The Brain Needs Meat’
https://www.youtube.com/watch?v=UR7H9xeMYME
‘WHO says red meat causes cancer?’
https://www.youtube.com/watch?v=xDgzgDSInt0
Psilocybin should be investigated for possible benefits, but it is safer – and legal – to eat like the apex predators we are designed to be.
Dr. Barry Groves, PphD – ‘What We Are Designed to Eat’
https://rumble.com/v33hg7e-the-carnivore-diet-what-we-are-designed-to-eat-barry-groves.html?e9s=src_v1_s%2Csrc_v1_s_o&sci=7e492228-c3d4-4d17-80a1-1f0590c6953f
Very good promising. There is definitely an urgent need for further studies on this. These studies should include other conditions that affect the brain, than just Alzheimer’s.
What is needed is a proper shakedown of the CAUSES. And, to be fair, when I see what happens to the elderly in care – the catering, the medications they are on, the unnecessary injections, the hours they spend put out to pasture in front of a huge TV – I don’t think this really is a case for Miss Marple.
uh huh sure turn alziemer patients into lunatics with hallucinations much better right?
Every so often this old chestnut makes a rerun doesn’t it. Hallucinogens are the cure for everything and the path to true spiritual knowledge as well – according to anyone who spent a wasted year or two out of their minds. If curing dementia was the mission, I’d start in the care home kitchen. I wouldn’t be calling for yet more pharmacy for the elderly.
Are you a part of the system called the constant fear…..?
So, Alzheimers’ (a thing barely heard of before the 1980s, by the way) is caused by magic mushroom deficiency? Who knew?
u have to stop all the poisoning first ( mission impossible ) then u will see a clear path . Stop the inflammation and the body will heal .
lookup the poisoning hasn’t stopped
Promising. Now to figure out the pathway by which it acts.
Who gave doctors the authority to give psychedelics, an experimental treatment, to people who cannot make such decisions for themselves?
project bluebird